Initial Study on 3D Porous Silk Fibroin Scaffold: Preparation and Morphology
نویسندگان
چکیده
Objective. The aim of the present study is to prepare a 3D porous silk fibroin scaffold with a hierachical structure that can meet the demands for bone tissue engineering. Materials and Methods. 3D fibroin scaffold was prepared by the methods of partial dissolution in acid solution and freeze drying fibroin solution. Results. The nets were composed of a mesh of randomly oriented fibers that ranged between 10 μm and 30 μm in diameter. Branchpoints and three dimensional open spaces were distributed throughout the structure with an average pore size of about 177.9± 40.0 μm. Conclusion. With the methods of non-woven silk fibroin net preparation and frozen-dried technics, it is possible to prepare a 3D porous silk fibroin scaffold with hierachical fine structure.
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